DUAL DNA METHYLATION PATTERNS IN THE CNS REVEAL DEVELOPMENTALLY POISED CHROMATIN AND MONOALLELIC EXPRESSION OF CRITICAL GENES.

Dual DNA methylation patterns in the CNS reveal developmentally poised chromatin and monoallelic expression of critical genes.

As a first step towards discovery of genes expressed from only one allele in the CNS, we click here used a tiling array assay for DNA sequences that are both methylated and unmethylated (the MAUD assay).We analyzed regulatory regions of the entire mouse brain transcriptome, and found that approximately 10% of the genes assayed showed dual DNA methy

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Glyoxylate Shunt and Pyruvate-to-Acetoin Shift Are Specific Stress Responses Induced by Colistin and Ceragenin CSA-13 in Enterobacter hormaechei ST89

ABSTRACT Ceragenins, including CSA-13, are cationic antimicrobials that target the bacterial cell envelope differently than colistin.However, the molecular basis of their action is not fully understood.Here, we examined the genomic and transcriptome responses by Enterobacter hormaechei after prolonged exposure to either CSA-13 or colistin.Resistanc

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